The infectious virion contains an inner «core particle» enclosing viral genome. The icosahedral core particle is made of 180 or 240 copies of the core protein, alternatively known as hepatitis B core antigen, or HBcAg. During this ‘window’ in which the host remains infected but is successfully clearing the virus, IgM antibodies specific to the hepatitis B core antigen (anti HBc IgM) may be the only serological evidence of disease.

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